The girl in Crash Bandicoot ended up being his sister, if I remember right. They changed quite a lot of stuff in the final product. I can't say I'm not glad they did, what we got was brilliant.
Rumour has it that Sony are going to make another All Stars game, so there might be a Crash game off the back of it or before it as a way to reintroduce him to people. I don't think Sony own the rights to Crash though, but if it means a new game I'll definitely give it a try.