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>> No. 8604 Anonymous
25th December 2022
Sunday 12:40 am
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I’ve noticed that antidepressants (SSRIS) make me far more resistant to alcohol. I can drink a lot more than I’m used to, without feeling as drunk.

What’s the biological explanation for that?

I’m pretty upset because I was always happy with being a lightweight, now I’m spending more money for less fun.
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>> No. 8605 Anonymous
25th December 2022
Sunday 12:44 am
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I’ve also noticed that when I am drunk, it impacts my motor skills more than it used to. I’m far more off-balance, etc. And I slur my words VERY heavily. This sounds like typical drunk behaviour but I’ve never had that before these drugs.
>> No. 8606 Anonymous
25th December 2022
Sunday 12:38 pm
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I've done a quick literature review and the answer seems to be "we don't really know". My best guess is that SSRIs are reducing the euphoric effects of alcohol, because your serotonin system has downregulated to compensate for the higher levels of serotonin in your bloodstream. I'd guess that the alcohol isn't actually impacting your motor skills more, you're just drinking more to try and get a buzz; SSRIs don't affect the GABA system, which is what causes the psychomotor effects of alcohol. SSRIs do indirectly affect the dopamine system, but the mechanisms are far too complex for me to speculate on.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826824/
>> No. 8607 Anonymous
25th December 2022
Sunday 8:10 pm
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>>8606
Ta lad.

>My best guess is that SSRIs are reducing the euphoric effects of alcohol, because your serotonin system has downregulated to compensate for the higher levels of serotonin in your bloodstream

Is there any way to counter that? I miss my buzz.
>> No. 8608 Anonymous
25th December 2022
Sunday 8:36 pm
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>>8607
>Is there any way to counter that? I miss my buzz.
Cold turkey on the SSRI's while relying exlusively on alcohol to medicate your depression. What could go wrong?
>> No. 8609 Anonymous
25th December 2022
Sunday 9:52 pm
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>>8608
Honestly, I am considering it. It would be just as effective and far more fun.

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